کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2012451 | 1067031 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential effects of glycine on the anticonvulsant activity of D-cycloserine and L-701,324 in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The anticonvulsant effects of D-cycloserine, which is a partial agonist of the glycine/N-methyl-D-aspartate (NMDA) receptor, and L-701,324, which is a selective and potent antagonist that acts at the glycine site, were studied in electroshock-induced seizures in mice. Glycine, which is a natural full agonist that acts at the glycine site, enhanced the seizure threshold-increasing effect of D-cycloserine. L-701,324 produced a marked increase in the seizure threshold, which was significantly reversed by the administration of glycine. These results suggest that indirect glycine/NMDA antagonistic mechanisms may be responsible for the anticonvulsant action of D-cycloserine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 63, Issue 5, September–October 2011, Pages 1231–1234
Journal: Pharmacological Reports - Volume 63, Issue 5, September–October 2011, Pages 1231–1234
نویسندگان
Wlaź Piotr, Poleszak Ewa,