18-Methoxycoronaridine blocks context-induced reinstatement following cocaine self-administration in rats

► Novel reinstatement paradigm that utilized music as a contextual CS in rats. ► Drug-paired music reinstated drug seeking and produced spatial conditioning. ► Drug-paired music significantly increased extracellular DA in the BLA of rats. ► 18-MC pretreatment blocks context-induced drug seeking and spatial conditioning.