کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2013105 1541880 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression profiling in neuropsychiatric disorders: Emphasis on glutamate receptors in bipolar disorder
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Expression profiling in neuropsychiatric disorders: Emphasis on glutamate receptors in bipolar disorder
چکیده انگلیسی

Functional genomics and proteomics approaches are being employed to evaluate gene and encoded protein expression changes with the tacit goal to find novel targets for drug discovery. Genome-wide association studies (GWAS) have attempted to identify valid candidate genes through single nucleotide polymorphism (SNP) analysis. Furthermore, microarray analysis of gene expression in brain regions and discrete cell populations has enabled the simultaneous quantitative assessment of relevant genes. The ability to associate gene expression changes with neuropsychiatric disorders, including bipolar disorder (BP), and their response to therapeutic drugs provides a novel means for pharmacotherapeutic interventions. This review summarizes gene and pathway targets that have been identified in GWAS studies and expression profiling of human postmortem brain in BP, with an emphasis on glutamate receptors (GluRs). Although functional genomic assessment of BP is in its infancy, results to date point towards a dysregulation of GluRs that bear some similarity to schizophrenia (SZ), although the pattern is complex, and likely to be more complementary than overlapping. The importance of single population expression profiling of specific neurons and intrinsic circuits is emphasized, as this approach provides informative gene expression profile data that may be underappreciated in regional studies with admixed neuronal and non-neuronal cell types.


► GWAS studies identified glutamate receptor candidate genes for bipolar disorder.
► Alterations in glutamate receptor genes were reviewed in bipolar disorder.
► Expression profiling of specific neurons and intrinsic circuits is emphasized.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 100, Issue 4, February 2012, Pages 705–711
نویسندگان
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