ReviewBiomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex

- Transplanted neural or endogenous neural stem cells can promote cortical regeneration.
- Strategies for cortical regeneration must address specific technical issues.
- Regenerative strategies include cell-cycle manipulation and engineered biomaterials.

The cerebral cortex is responsible for higher functions of the central nervous system (CNS), such as movement, sensation, and cognition. When the cerebral cortex is severely injured, these functions are irreversibly impaired. Although recent neurobiological studies reveal that the cortex has the potential for regeneration, therapies for functional recovery face some technological obstacles. Biomaterials have been used to evoke regenerative potential and promote regeneration in several tissues, including the CNS. This review presents a brief overview of new therapeutic strategies for cortical regeneration from the perspectives of neurobiology and biomaterial engineering, and discusses a promising technology for evoking the regenerative potential of the cerebral cortex.