X-ray Crystal Structure of the UCS Domain-Containing UNC-45 Myosin Chaperone from Drosophila melanogaster

► The UCS and central domains of UNC-45 consist of five armadillo repeat subdomains ► The N-terminal TPR domain exhibits flexibility relative to central and UCS domains ► UNC-45 is more elongated and exhibits conformational flexibility in solution ► Sequence identity and deleterious mutations identify a myosin-interaction surface