کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2030321 1071080 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Complement and the Multifaceted Functions of VWA and Integrin I Domains
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Complement and the Multifaceted Functions of VWA and Integrin I Domains
چکیده انگلیسی

The recent crystal structure of complement protein component C2a reveals an interface between its VWA and serine protease domains that could not exist in the zymogen C2. The implied change in VWA domain conformation between C2 and C2a differs from that described for other VWA domains, including the I domains in integrins. Here, the remarkable diversity in both conformational regulation and ligand binding among VWA domains that function in complement, hemostasis, cell adhesion, anthrax toxin binding, vesicle transport, DNA break repair, and RNA quality control is reviewed. Finally, implications for metastability of complement convertases are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 14, Issue 11, November 2006, Pages 1611–1616
نویسندگان
,