Contribution of proteomics to the management of vascular disorders

• How to design a state-of-the art proteomic/metabolomic analysis.
• Latest advances in atherothrombosis through proteomics/metabolomics.
• Potential of systems biology for integrating omics projects.
• Biomarker and therapeutical target implementation in the clinic.

Vascular disorders, and in particular atherothrombosis, are currently a leading cause of morbidity and mortality in Western societies. Proteomics research into these disorders has helped improving our knowledge of the underlying mechanisms involved in the development of atherothrombosis, as well as providing novel biomarkers to diagnose and for the prognosis of this disease. However, the application of these advances into clinical use has not followed this trend. In this review we explore the potential of Proteomics and Metabolomics for the management of vascular disorders, paying special attention to atherothrombosis and aiming to guide the reader from the experimental design of proteomic analysis through the initial discovery phase to the clinical implementation of biomarkers or therapeutic targets (Fig. 1), providing state-of-the-art proteomic studies to exemplify the concepts addressed.

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