کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2030572 1071219 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DNA–protein crosslink repair: proteases as DNA repair enzymes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
DNA–protein crosslink repair: proteases as DNA repair enzymes
چکیده انگلیسی

DNA–protein crosslinks (DPCs) are highly toxic DNA lesions because they interfere with DNA transactions. The recent discovery of a yeast protease that processes DPCs proteolytically raises the question whether DPC proteases also exist in higher eukaryotes. We argue here that the yeast enzyme, Wss1 (weak suppressor of smt3), is a member of a protease family whose mammalian representative is Spartan (SprT-like domain-containing protein)/DVC1 (DNA damage protein targeting VCP). DPC proteases may thus be common to all eukaryotes where they function as novel guardians of the genome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 40, Issue 2, February 2015, Pages 67–71
نویسندگان
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