کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2041717 | 1073171 | 2016 | 13 صفحه PDF | دانلود رایگان |
• The gut immune receptor LRRC19 is involved in host-microbiota interactions
• LRRC19-associated chemokines control immune cell recruitment and gut inflammation
• Chemokines are regulated by REG protein-mediated gut microbiotas
• Lactobacillus may modulate the expression of REG proteins through LRRC19
SummaryCommensal microbes are necessary for a healthy gut immune system. However, the mechanism involving these microbes that establish and maintain gut immune responses is largely unknown. Here, we have found that the gut immune receptor leucine-rich repeat (LRR) C19 is involved in host-microbiota interactions. LRRC19 deficiency not only impairs the gut immune system but also reduces inflammatory responses in gut tissues. We demonstrate that the LRRC19-associated chemokines CCL6, CCL9, CXCL9, and CXCL10 play a critical role in immune cell recruitment and intestinal inflammation. The expression of these chemokines is associated with regenerating islet-derived (REG) protein-mediated microbiotas. We also found that the expression of REGs may be regulated by gut Lactobacillus through LRRC19-mediated activation of NF-κB. Therefore, our study establishes a regulatory axis of LRRC19, REGs, altered microbiotas, and chemokines for the recruitment of immune cells and the regulation of intestinal inflammation.
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Journal: - Volume 14, Issue 4, 2 February 2016, Pages 695–707