کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2041849 1073175 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preservation of Gene Duplication Increases the Regulatory Spectrum of Ribosomal Protein Genes and Enhances Growth under Stress
ترجمه فارسی عنوان
حفظ تکثیر ژن طیف تنظیم کننده ژن پروتئین ریبوزومی را افزایش می دهد و رشد را تحت فشار قرار می دهد
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• Duplicated ribosomal protein genes (RPGs) are asymmetrically expressed and regulated
• Transcription termination regulates the expression of non-intron-containing RPGs
• Differences in expression levels enforce the subfunctionalization of duplicated RPGs
• Duplication of RPGs improves cell fitness and growth under stress

SummaryIn baker’s yeast, the majority of ribosomal protein genes (RPGs) are duplicated, and it was recently proposed that such duplications are preserved via the functional specialization of the duplicated genes. However, the origin and nature of duplicated RPGs’ (dRPGs) functional specificity remain unclear. In this study, we show that differences in dRPG functions are generated by variations in the modality of gene expression and, to a lesser extent, by protein sequence. Analysis of the sequence and expression patterns of non-intron-containing RPGs indicates that each dRPG is controlled by specific regulatory sequences modulating its expression levels in response to changing growth conditions. Homogenization of dRPG sequences reduces cell tolerance to growth under stress without changing the number of expressed genes. Together, the data reveal a model where duplicated genes provide a means for modulating the expression of ribosomal proteins in response to stress.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 13, Issue 11, 22 December 2015, Pages 2516–2526
نویسندگان
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