Advances in dissecting endomembrane trafficking with small molecules

▶ The highly dynamic nature of the vesicle trafficking is a challenge to biologists. ▶ Chemical genomics permits the real-time study of endomembrane trafficking processes. ▶ Chemical inhibition of vesicle trafficking can connect network vesicles with cargoes. ▶ However, effective network dissection requires the discovery of many new molecules. ▶ Screening advances and complex systems-oriented analysis will drive new discoveries.