کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2075525 | 1079339 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Perilla oil rich in α-linolenic acid inhibits neuronal apoptosis and the expression of inflammation-mediator protein in apoE KO mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
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چکیده انگلیسی
ApoE KO mice and its wild type mice were fed atherogenic diet containing either 10% lard (LD) or perilla oil (PE). In apoE KO group fed PE (APE), brain total cholesterol and trigrlyceride concentrations were reduced by 8 and 17%, respectively, than apoE KO group fed LD (ALD). Brain lipid peroxidation and NFκB expression of APE were inhibited by 20.83 and 60% compared to those for the ALD. Neuronal apoptosis of APE was significantly reduced by 37% than ALD group. These results suggest that PE would ameliorate the brain damage under hypercholesterolemia induced by atherogenic diet via inhibiting the oxidative stress and inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biocatalysis and Agricultural Biotechnology - Volume 1, Issue 2, April 2012, Pages 167–173
Journal: Biocatalysis and Agricultural Biotechnology - Volume 1, Issue 2, April 2012, Pages 167–173
نویسندگان
Jeongeun Seong, Yeong Ok Song,