کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2142088 1088306 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Single agent maintenance therapy for advanced stage non-small cell lung cancer: A meta-analysis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Single agent maintenance therapy for advanced stage non-small cell lung cancer: A meta-analysis
چکیده انگلیسی

BackgroundMaintenance therapy is a new treatment paradigm for advanced non-small cell lung cancer (NSCLC). We conducted a meta-analysis of randomized studies with single agent maintenance therapy.MethodsAn electronic literature search of public databases (MEDLINE, EMBASE, Cochrane library) and manual search of relevant conference proceedings was performed. A formal meta-analysis was conducted using Comprehensive Meta Analysis software (Version 2.0). Outcome data were pooled and reported as hazard ratio (HR). The primary outcome of interest was overall survival (OS) and secondary outcome was progression free survival (PFS).ResultsTwelve studies were included (5 meeting abstracts, 7 full manuscripts) with a total of 4286 patients (maintenance arm/control arm – 2449/1837, median age 61 years, males – 69%). The OS (HR 0.86, 95% confidence intervals [CI] 0.80–0.92; P = 0.0003) and PFS (HR 0.80, 95% CI 0.77–0.84; P < 0.0001) were superior with maintenance therapy. ‘Switch’ maintenance was associated with significant OS and PFS improvement (OS HR 0.84, 95% CI 0.77–0.91; P = 0.00026; PFS HR 0.62, 95% CI 0.57–0.67; P < 0.0001). Despite a modest improvement in PFS (HR 0.90, 95%CI 0.85–0.95; P = 0.007), “continuation” maintenance was not associated with survival benefit (HR 0.927, 95%CI 0.78–1.09; P = 0.33). Improvements in OS and PFS were observed with both EGFR-targeted agents (HR 0.83, 95% CI 0.74–0.92; P = 0.004; HR 0.64, 95% CI 0.58–0.71 P < 0.0001) and cytotoxic agents (HR 0.89, 95% CI 0.80–0.98; P = 0.018; HR 0.85, 95% CI 0.80–0.89; P < 0.0001).ConclusionsSingle agent maintenance therapy improves overall survival, though statistical significance was only noted with ‘switch’ maintenance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 77, Issue 2, August 2012, Pages 331–338
نویسندگان
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