Evaluation of a bolus/infusion protocol for 11C-ABP688, a PET tracer for mGluR5

It is demonstrated that with a B/I protocol the 11C-ABP688 distribution in late scans reflects the pattern of the total distribution volume and is therefore a measure for the density pattern of mGluR5. The early scans following injection are related to blood flow, although not in a fully quantitative manner. The advantage of the B/I protocol is that no arterial blood sampling is required, which is advantageous in clinical studies.