کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2402617 | 1102827 | 2012 | 8 صفحه PDF | دانلود رایگان |
Vaccination is one of the most effective medical interventions. However, optimization of existing as well as design of new vaccines is still mostly conducted empirically; a rational approach to vaccine design is largely prohibited by the lack of insight into the relevant mechanisms underlying immune-mediated protection. To delineate the impact of variables on immune memory formation following vaccination, we took advantage of a trial assessing the role of the age of the recipient and the number of administered doses of the quadrivalent HPV vaccine in a well-characterized longitudinal cohort of girls and young women. We found that age of the recipient and the number of doses administered differentially impact the development of B and T cell memory. Specifically, age of the recipient significantly impacted generation of HPV 18-specific B cell memory, while the number of vaccine doses displayed a significant effect on the development of HPV-specific T cell memory. Our data indicate that rational design of vaccines has to be tailored according to the desired induction of B and/or T cell memory.
► Measured B and T cell memory of girls and women after 2 or 3 doses of HPV vaccine.
► Both dose and age impacted B cell immune memory response.
► Dose, but not age, impacted T cell memory response; 3 doses led to higher response.
Journal: Vaccine - Volume 30, Issue 24, 21 May 2012, Pages 3572–3579