کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2403914 | 1102938 | 2012 | 11 صفحه PDF | دانلود رایگان |
Many jurisdictions have implemented universal human papillomavirus (HPV) immunization programs in preadolescent females. However, the cost-effectiveness of modified cervical screening guidelines and/or catch-up immunization in older females in Canada has not been evaluated. We conducted a cost-utility analysis of screening and immunization with the bivalent vaccine for the Canadian setting from the Ministry of Health perspective. We used a dynamic model to capture herd immunity and included cross-protection against strains not included in the vaccine. We found that adding catch-up immunization to the current program would be cost-effective, and that combining catch-up immunization with delaying the age at which screening is first initiated could result in cost savings and net health gains.
► We conduct a cost utility analysis of HPV catch-up immunization and cervical screening strategies.
► The analysis uses a dynamic model that captures herd immunity and vaccine cross-protection.
► Adding catch-up immunization to an existing program in pre-adolescent females is cost-effective.
► Combining catch-up immunization with a delay in the age of initial screening is cost-saving.
Journal: Vaccine - Volume 30, Issue 2, 5 January 2012, Pages 425–435