Cost-effectiveness analysis of behavioral interventions to improve vaccination compliance in homeless adults

AimsTo estimate the cost-effectiveness of three behavioral interventions provided to enhance hepatitis A virus (HAV) and hepatitis B virus (HBV) joint vaccination (HAV/HBV) compliance among homeless persons living in Los Angeles County.ScopeA cost-effectiveness analysis (CEA) based on data from a randomized trial where the costs and compliance data from the trial are incorporated into two Markov models, simulating the natural history of acute and chronic hepatitis infection, following HAV/HBV vaccination.ConclusionsReductions in HBV-related disease is cost-effective to society and is associated with substantial improvements in quality of life.