کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2409139 | 1103209 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The lpxM mutant of the live vaccine Yersinia pestis EV NIIEG strain synthesising a less toxic penta-acylated lipopolysaccharide was found to be avirulent in mice and guinea pigs, notably showing no measurable virulence in Balb/c mice which do retain some susceptibility to the parental strain itself. Twenty-one days after a single injection of the lpxM-mutant, 85–100% protection was achieved in outbred mice and guinea pigs, whereas a 43% protection rate was achieved in Balb/c mice given single low doses (103 to 2.5 × 104 CFU) of this vaccine. A subcutaneous challenge with 2000 median lethal doses (equal to 20,000 CFU) of fully virulent Y. pestis 231 strain, is a 6–10-fold higher dose than that which the EV NIIEG itself can protect against.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 44, 1 November 2007, Pages 7620–7628
Journal: Vaccine - Volume 25, Issue 44, 1 November 2007, Pages 7620–7628
نویسندگان
V.A. Feodorova, L.N. Pan’kina, E.P. Savostina, L.V. Sayapina, V.L. Motin, S.V. Dentovskaya, R.Z. Shaikhutdinova, S.A. Ivanov, B. Lindner, A.N. Kondakova, O.V. Bystrova, N.A. Kocharova, S.N. Senchenkova, O. Holst, G.B. Pier, Y.A. Knirel, A.P. Anisimov,