کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2409675 | 1103227 | 2007 | 7 صفحه PDF | دانلود رایگان |
Since drug-activated γδ T cells promote dendritic cell (DC) maturation, we analyzed the effect of combining γδ T cell specific drugs with BCG in vitro. BCG-induced DC maturation was increased by bromohydrin-pirophosphate (BrHPP) or zoledronate (Zol)-activated γδ T cells. Specifically, the co-culture with activated Vγ9Vδ2 T cells with BCG-infected DC resulted in a significant increase of the expression of CD80, CD86, CD40 and CD25 molecules on DC. Moreover, DC were able to produce increased levels of TNF-α and synthesize ex novo IL-15 without altering the IL-10/IL-12 immunoregulatory pathway. Finally, the Th1 immunity induced by BCG-infected DC on naïve CD4 T cells was increased by γδ T cell activation with BrHpp or Zol. These data indicate that γδ T cell triggering drugs could be used to enhance the BCG induced Th1 immunity.
Journal: Vaccine - Volume 25, Issue 6, 22 January 2007, Pages 1023–1029