کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2438484 | 1107718 | 2007 | 4 صفحه PDF | دانلود رایگان |
SummaryThe expression of interleukin-12 (IL-12) and interferon-gamma (IFN-γ) was examined immunohistochemically in the lungs of pigs aged 21 days infected experimentally with Mycoplasma hyopneumoniae (Mh). Ten pigs were inoculated intranasally with Mh and killed in pairs weekly from 7 to 35 days post-infection (dpi). Immunolabelling for IL-12 and IFN-γ was usually associated with inflammation, particularly in macrophages and lymphocytes in the thickened alveolar septa and in the hyperplastic bronchus-associated lymphoid tissue (BALT). Cells positive for both cytokines were detected at 7 dpi, their numbers increasing at 14 and 21 dpi, and slightly decreasing thereafter. The results suggest that IL-12 and IFN-γ play a role in pulmonary defence mechanisms against Mh infection.
Journal: Journal of Comparative Pathology - Volume 136, Issue 1, January 2007, Pages 79–82