کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2469255 1555453 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Abortion due to Salmonella enterica serovar Abortusovis (S. Abortusovis) in ewes is associated to a lack of production of IFN-γ and can be prevented by immunization with inactivated S. Abortusovis vaccine
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Abortion due to Salmonella enterica serovar Abortusovis (S. Abortusovis) in ewes is associated to a lack of production of IFN-γ and can be prevented by immunization with inactivated S. Abortusovis vaccine
چکیده انگلیسی

Salmonellosis due to Salmonella enterica serovar Abortusovis (S. Abortusovis) is mainly characterized by abortionin sheep. Little is known about the immune response, which develops in the host as a result of infection. We evaluated the immune response of pregnant ewes vaccinated and successively exposed to full virulent S. Abortusovis. We found that vaccine constituted by inactivated S. Abortusovis induced both humoral and cellular-mediated immune response and that it provided protection against a challenge infection due to a fully virulent S. Abortusovis. Furthermore, we found an association between the lack of capability to produce IFN-γ and abortion. This evidence suggests that protection against abortion can be associated to an IFN-γ mediated mechanism. Our findings represent an interesting insight to better understand the interplay between host and S. Abortusovis and the effector mechanisms underpinning immune-based protection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Microbiology - Volume 121, Issues 3–4, 15 April 2007, Pages 330–337
نویسندگان
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