کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2473685 1113044 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Orally-transmitted Chagas disease: Epidemiological, clinical, serological and molecular outcomes of a school microepidemic in Chichiriviche de la Costa, Venezuela
ترجمه فارسی عنوان
بیماری Chagas انتقال شده از طریق دهان؛ پیامدهای اپیدمیولوژیک، بالینی، سرولوژیک و مولکولی یک میکروپیدمی مدرسه در Chichiriviche de la Costa، ونزوئلا
کلمات کلیدی
بیماری Chagas؛ انتقال دهان؛ بزاق؛ Foodborne؛ Chichiriviche de la Costa؛ ونزوئلا
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی

Oral transmission of Trypanosoma cruzi is a frequent cause of acute Chagas disease (ChD). In the present cross-sectional study, we report the epidemiological, clinical, serological and molecular outcomes of the second largest outbreak of oral ChD described in the literature. It occurred in March 2009 in Chichiriviche de la Costa, a rural seashore community at the central littoral in Venezuela. The vehicle was an artisanal guava juice prepared at the local school and Panstrongylus geniculatus was the vector involved. TcI genotype was isolated from patients and vector; some showed a mixture of haplotypes. Using molecular markers, parasitic loads were high. Eighty-nine cases were diagnosed, the majority (87.5%) in school children 6–15 years of age. Frequency of symptomatic patients was high (89.9%) with long-standing fever in 87.5%; 82.3% had pericardial effusion detected by echocardiogram and 41% had EKG abnormalities. Three children, a pregnant woman and her stillborn child died (5.6% mortality). The community was addressed by simultaneous determination of specific IgG and IgM, confirmed with indirect hemagglutination and lytic antibodies. Determination of IgG and IgA in saliva had low sensitivity. No individual parasitological or serological technique diagnosed 100% of cases. Culture and PCR detected T. cruzi in 95.5% of examined individuals. Based on the increasing incidence of oral acute cases of ChD, it appears that food is becoming one of the most important modes of transmission in the Amazon, Caribbean and Andes regions of America.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parasite Epidemiology and Control - Volume 1, Issue 2, June 2016, Pages 188–198
نویسندگان
, , , , , , , , , , , , ,