کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2483277 | 1114214 | 2014 | 9 صفحه PDF | دانلود رایگان |
Poly( methacrylic acid-co-butyl methacrylate) copolymer was synthesized which showed more than tenfold swelling above the pH of 4.5 within a narrow (0.5) pH range with the monomer composition of 85 mol% MAA and 15 mol% BMA. The water uptake properties of the prepared copolymers were adjustable by the monomer composition. Thin films were prepared consisting of a lower layer of silver nanoparticles (~ 0.033 mg/cm2) and an upper layer of pH-sensitive polymer (~ 2.0 mg/cm2). The AgNPs (d = ~ 20 nm) content of the layers was 1.64 wt%. Below pH 4.5,17 % of the active agent content was released after 1 h, however, at higher pH values (> 4.5) 100 % of the AgNPs left the thin layer. The antifungal effect was successful against Candida albicans, because the treatment with 10 ppm AgNPs dispersion killed 100 % of initial (~ 2.85 x 103 cfu/mL) yeast after 30 min. The minimal effective concentration of AgNPs is ~ 28500 cfu Candida albicans/mg AgNP for a contact time of 30 min.
Journal: Journal of Drug Delivery Science and Technology - Volume 24, Issue 6, 2014, Pages 628-636