کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2483283 | 1114214 | 2014 | 5 صفحه PDF | دانلود رایگان |
In this study, as-synthesized mesoporous silica preloaded with pyrene was synthesized, and then its physical properties and molecular state of pyrene were evaluated. The product had mesoporous structure from small-angle X-ray scattering and scanning electron microscopy measurements. Nitrogen gas adsorption and solid-state NMR measurements confirmed that the pore spaces were filled with Pluronic P123 (P123) and pyrene. Mobility of P123 inside the pore was investigated by solid-state NMR measurement. Mobility of hydrophilic PEO chain decreased in the pore. Solid-state fluorescence measurement was used to examine the encapsulation state of pyrene. Molecular state of pyrene was compared before and after the calcination process. At a low loading amount, pyrene-loaded calcined mesoporous silica showed the superior excimer emission, whereas pyrene-loaded as-synthesized mesoporous silica gave the predominant monomer emission. The results revealed that the presence of P123 could contribute to the dispersion improvement of pyrene at the molecular level.
Journal: Journal of Drug Delivery Science and Technology - Volume 24, Issue 6, 2014, Pages 673-677