کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2485073 1114344 2012 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Production of PEGylated Nanocapsules through Solvent Displacement in Confined Impinging Jet Mixers
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Production of PEGylated Nanocapsules through Solvent Displacement in Confined Impinging Jet Mixers
چکیده انگلیسی
The growth of importance of nanocapsules (and other particulate systems) in different fields requires fast and reproducible methods for their production. Confined impinging jet mixers were successfully used for the production of nanospheres and are now tested for the first time for the production of nanocapsules. This work focuses on the understanding of formation mechanisms and on the quantification of the effect of the most important operating parameters involved in their production. Solvent displacement is employed here for the assembly of the nanocapsules by using a PEGylated derivative of cyanoacrylate as copolymer. A comparison with nanospheres obtained under the same operating conditions is also reported. Results show that the oil-to-copolymer mass ratio (MR) is the main factor affecting the final size distribution and that small nanocapsules are obtained only at low oil-to-copolymer MR. The effect of mixing is significant, proving that mixing of solvent and antisolvent also affects the final size distribution; this depends mainly on the inlet jet velocity, but the size of the mixer is also important. The Reynolds number may be useful to take this into account for geometrically similar systems. Quenching by dilution allows to stabilize the nanocapsules, evidencing the role of aggregation and ripening. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 7, July 2012, Pages 2490-2501
نویسندگان
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