کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2486112 | 1114375 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cyclodextrin Multicomponent Complexation and Controlled Release Delivery Strategies to Optimize the Oral Bioavailability of Vinpocetine
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In the present work, to maintain a suitable blood level of vinpocetine (VP) for a long period of time, VPâcyclodextrinâtartaric acid multicomponent complexes were prepared and formulated in hydroxypropylmethylcellulose matrix tablets. In vitro and in vivo performances of these formulations were investigated over a VP immediate release dosage form. Solubility studies were performed to evaluate the drug pH solubilization profile and to assess the effect of multicomponent complexation on VP solubility. The drug release process was investigated using United States Pharmacopeia apparatus 3 and a comparative oral pharmacokinetic study was subsequently undertaken in rabbits. Solubility studies denoted the pHâsolubility dependence of VP and solubility improvement attained by complexation. Dissolution results showed controlled and almost complete release behavior of VP over a 12âh period from complex hydroxypropylmethylcelluloseâbased formulations. A clear difference between the pharmacokinetic patterns of VP immediate release and VP complexâbased formulations was revealed. The area under the plasma concentrationâtime curve after oral administration of complexâbased formulations was 2.1-2.9 times higher than that for VP immediate release formulation. Furthermore, significant differences found for mean residence time, elimination halfâlife, and elimination rate constant values corroborated prolonged release of VP from complexâbased formulations. These results suggest that the oral bioavailability of VP was significantly improved by both multicomponent complexation and controlled release delivery strategies. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96:2018-2028, 2007
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 8, August 2007, Pages 2018-2028
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 8, August 2007, Pages 2018-2028
نویسندگان
Laura S.S. Ribeiro, AmÃlcar C. Falcão, João A.B. PatrÃcio, Domingos C. Ferreira, Francisco J.B. Veiga,