Engineering of Pharmaceutical Materials: An Industrial Perspective

Crystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of drugs and excipients for successful pharmaceutical formulation and process development. Existing and emerging manufacturing as well as co-processing technologies being applied in the pharmaceutical industry are also presented together with selected examples of crystal form design, crystal form selection and crystal modifications for illustration purposes. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97: 2855-2877, 2008