Ropren® is a polyprenol preparation from coniferous plants that ameliorates cognitive deficiency in a rat model of beta-amyloid peptide-(25–35)-induced amnesia

This study assesses the efficacy of a fixed dose of Ropren® (a plant preparation isolated from the neutral fraction of an extract of spruce needles) on cognitive impairment in rats with β-amyloid peptide-(25–35)-induced amnesia. Ropren® was administered at a dose of 8.6 mg/kg for 28 days, per os, to rats with β-amyloid peptide-(25–35)-induced amnesia. Cognitive performance was assessed using the passive avoidance paradigm and the Morris water maze and behavior was assessed using the open field test. After four weeks, Ropren® treatment significantly improved non-spatial and spatial learning in rats with β-amyloid peptide-(25–35)-induced amnesia. The results of the present study suggest that Ropren®, a novel plant preparation, ameliorates cognitive deficiencies in an animal model relevant to Alzheimer's disease.