کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2500743 1557305 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Near infrared spectroscopy to monitor drug release in-situ during dissolution tests
ترجمه فارسی عنوان
طیف سنجی نزدیک به مادون قرمز برای نظارت بر آزادی دارو در محل آزمایشات انحلال
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Dissolution tests can be used to demonstrate suitable in vivo drug release through in vivo/in vitro correlations. This work explores the possibility of using near infrared spectroscopy (NIRS) to monitor in-situ dissolution tests. It aims at expanding surrogate methods in quality control of drug products. Laboratory designed tablets of an immediate-release formulation containing folic acid and four excipients were used as case study. The dissolution tests were performed on a 1 L vessel filled with 500 ml of Milli-Q water with a rotating paddle apparatus (apparatus 2, Ph. Eur.) at 50 rpm and 37 ± 0.5 °C. Near infrared (NIR) spectra were acquired in-situ with a transflectance probe connected to a Fourier-transform near infrared spectrometer. NIR spectra were regressed against folic acid concentration by partial least squares (PLS) regression. Folic acid concentrations during dissolution tests were obtained by periodically sampling the dissolution vessel and resourcing to an UV method. The proposed real-time NIR method was tested on a validation run yielding a root mean squared error of 0.25 μg ml−1 (0.16 μg ml−1 for the calibration runs) and a R2 of 0.93 (0.95 for the calibration runs). The results suggest that NIRS is a suitable analytical technique for monitoring in-situ dissolution tests.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 513, Issues 1–2, 20 November 2016, Pages 1–7
نویسندگان
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