کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2500794 1557307 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and physicochemical properties of polyacrylamide nanoparticles as photosensitizer carriers
ترجمه فارسی عنوان
سنتز و خواص فیزیکی و شیمیایی نانوذرات پلی آکریل آمید به عنوان حامل های فتوسنتز کننده
کلمات کلیدی
فتوسنتززرها، نانوکاریس، درمان فوتودینامیک، مشتقات فنزین، مشتقات فنوتیازین
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

At present, polyacrylamide nanoparticles are attractive to drug delivery. However, some physicochemical characteristics of these nanoparticles still need to be further improved in practice. Polyacrylamide nanoparticles with an average size of 80 nm and a zeta potential of −30 mV were synthesized and used as photosensitizer carriers. The new monobrominated derivatives and parent compounds were the photosensitizers for the photodynamic therapy loaded in the nanocarrier.The physicochemical characterization of the prepared nanoparticles, drug loading, the ability to generate singlet oxygen and chemical stability were investigated.The novel tested nanoparticles exhibited a loading percentage of between 80 and 99%, higher generation of singlet oxygen and good stability in comparison with the corresponding starting reagent.According to these results, the novel polyacrylamide nanoparticles are excellent candidates for drug vehiculization.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 512, Issue 1, 15 October 2016, Pages 213–218
نویسندگان
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