کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2500917 1557314 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Toward predicting tensile strength of pharmaceutical tablets by ultrasound measurement in continuous manufacturing
ترجمه فارسی عنوان
پیش بینی استحکام کششی از قرص های دارویی با اندازه گیری اولتراسوند در تولید مداوم
کلمات کلیدی
استحکام کششی، مدول یانگ، سونوگرافی، ویژگی های مکانیکی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

An ultrasound measurement system was employed as a non-destructive method to evaluate its reliability in predicting the tensile strength of tablets and investigate the benefits of incorporating it in a continuous line, manufacturing solid dosage forms. Tablets containing lactose, acetaminophen, and magnesium stearate were manufactured continuously and in batches. The effect of two processing parameters, compaction force and level of shear strain were examined. Young's modulus and tensile strength of tablets were obtained by ultrasound and diametrical mechanical testing, respectively. It was found that as the blend was exposed to increasing levels of shear strain, the speed of sound in the tablets decreased and the tablets became both softer and mechanically weaker. Moreover, the results indicate that two separate tablet material properties (e.g., relative density and Young's modulus) are necessary in order to predict tensile strength. A strategy for hardness prediction is proposed that uses the existing models for Young's modulus and tensile strength of porous materials. Ultrasound testing was found to be very sensitive in differentiating tablets with similar formulation but produced under different processing conditions (e.g., different level of shear strain), thus, providing a fast, and non-destructive method for hardness prediction that could be incorporated to a continuous manufacturing process.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 507, Issues 1–2, 30 June 2016, Pages 83–89
نویسندگان
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