کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2512296 1118336 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The therapeutic potential of histamine receptor ligands in inflammatory bowel disease
ترجمه فارسی عنوان
پتانسیل درمانی لیگاندهای گیرنده هیستامین در بیماری التهابی روده ای
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

In the intestine of patients suffering from inflammatory bowel disease concentrations of histamine are increased compared to healthy controls. Genetic ablation of histamine production in mice ameliorates the course of experimentally induced colitis. These observations and first pharmacological studies indicate a function of histamine in the pathogenesis of inflammatory bowel disease. However, a closer examination reveals that available data are highly heterogeneous, limiting the rational design of strategies addressing specific histamine receptor subtypes as possible target for pharmacological interaction. However, very recently first clinical data indicate that antagonism at the histamine receptor subtype H4 provides a beneficial effect in at least the skin. Here, we discuss the available data on histamine effects and histamine receptor subtype functions in inflammatory bowel disease with a special emphasis on the histamine H4-receptor.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 91, Issue 1, 1 September 2014, Pages 12–17
نویسندگان
, ,