Intestinal stem cells and inflammation

• The intestinal crypt is comprised of at least two stem cell/progenitor populations.
• Lgr5+ stem cells are susceptible to epithelial injury in the acute setting.
• Reserve stem cells or progenitors promote epithelial regeneration.
• Multiple pathways and inflammatory factors modulate intestinal stem cells.

The intestinal epithelium is renewed every 3–5 days from at least two principal stem cell pools. Actively cycling crypt based columnar (CBC) Lgr5+ cells and slower cycling Bmi1-expressing or Krt19-expressing cells maintain the small intestinal and colonic epithelium in homeostasis and injury. Following acute epithelial damage, Lgr5+ stem cells are susceptible to injury and a reserve stem cell or progenitor pool is responsible for regeneration of the epithelium. Current data suggests that intestinal stem cells respond to inflammatory signals to modulate their expansion during epithelial regeneration. Here, we review how inflammation and injury affect intestinal and colonic stem cells.