Oxidized phospholipid signaling in immune cells

Oxidized phospholipids (oxPLs) that can be generated either enzymatically or non-enzymatically are fast becoming recognized as important signaling mediators of the immune system. Hundreds of structures exist, but only a small fraction have been studied in detail. Their known activities include regulation of adhesion molecule expression, pro-coagulant activity and inhibition of Toll-like receptor signaling, and several have been detected in models of human and animal disease. In this review, the most studied structures of oxPLs will be summarized, along with descriptions of their known biological actions. Subsequently, the focus will be on the more recently described forms generated acutely by lipoxygenases (LOX) in human and murine immune cells.

► Phospholipid oxidation during activation of immune cells.
► Oxidized phospholipids are pathophysiological signaling mediators.
► Generation of novel bioactive lipids in vascular cells by lipoxygenases.