کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2531057 1558902 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The high-affinity immunoglobulin E receptor as pharmacological target
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
The high-affinity immunoglobulin E receptor as pharmacological target
چکیده انگلیسی

The high-affinity receptor for immunoglobulin E is expressed mainly on mast cells and basophils, but also on neutrophils, eosinophils, platelets, monocytes, Langerhans and dendritic cells, airway smooth muscle cells and some nerve cells. Its main function is, upon its engagement by IgE and specific antigen, to trigger a powerful defense against invading pathogens and a rapid neutralization of dangerous toxic substances introduced in the body. This powerful response could be wielded against tumors. But, when control over this receptor is lost, its unchecked activation can induce an array of diseases, some of which can lead to death. In this review we will summarize the pharmacological approaches and strategies that are currently used, or under study, to harness or wield activation of this receptor for therapeutic purposes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 778, 5 May 2016, Pages 24–32
نویسندگان
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