کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2550724 1560580 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of oxidative stress on platelet hyperreactivity during aging
ترجمه فارسی عنوان
نقش استرس اکسیداتیو بر پرکاریابیت پلاکتی در هنگام پیری
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

Thrombotic events are common causes of morbidity and mortality in the elderly. Age-accelerated vascular injury is commonly considered to result from increased oxidative stress. There is abundant evidence that oxidative stress regulate several components of thrombotic processes, including platelet activation. Thus oxidative stress can trigger platelet hyperreactivity by decreasing nitric oxide bioavailability. Therefore oxidative stress measurement may help in the early identification of asymptomatic subjects at risk of thrombosis. In addition, oxidative stress inhibitors and platelet-derived nitric oxide may represent a novel anti-aggregation/-activation approach. In this article the relative contribution of oxidative stress and platelet activation in aging is explored.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 148, 1 March 2016, Pages 17–23
نویسندگان
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