کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2554114 | 1124948 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of tight blood pressure control on glomerular hypertrophy in a model of genetic hypertension and experimental diabetes mellitus
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کلمات کلیدی
angiotensin antagonist - آنتاگونیست آنژیوتانسینCell replication - تکثیر سلولیDiabetes mellitus - دیابت قندیHypertension - فشار خون بالاFibronectin - فیبرونکتینangiotensin-converting enzyme inhibitor - مهارکننده آنزیم تبدیلکننده آنژیوتانسینDiabetic nephropathy - نفروپاتی دیابتیCell hypertrophy - هیپرتروفی سلولی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of this study was to evaluate the effect of prevention of hypertension on glomerular hypertrophy, renal cell replication and accumulation of glomerular fibronectin in a model of genetic hypertension and experimental diabetes. Four-week-old streptozotocin induced spontaneously hypertensive rats (SHR) were randomized for no treatment, or for treatment with captopril, losartan or triple therapy (hydrochlorothiazide, reserpine and hydralazine) for 20 days. Increase in systolic blood pressure was equally prevented by captopril (118 ± 15 mmHg), losartan (111 ± 9) and triple therapy (112 ± 14, p < 0.0001). Glomerular size was higher (p < 0.005) in diabetic SHR (27,300 ± 2130 μm2) compared with non-diabetic SHR (23,800 ± 307). The antihypertensive therapy with captopril (23,900 ± 175), losartan (23,800 ± 120), and triple therapy (23,400 ± 210) prevented the glomerular enlargement in diabetic SHR. Glomerular expression of fibronectin was increased in diabetic SHR (7.61 ± 1.22 densitometric unit) as compared to the controls (2.27 ± 2.15, p < 0.0001), and was decreased (p < 0.0001 vs diabetic SHR) with captopril (2.49 ± 1.42), losartan (1.57 ± 1.1) and triple therapy (2.04 ± 1.42). The number of replicating glomerular cell significantly decreased in diabetic SHR and it was restored by all three antihypertensive regimes. The glomerular expression of p27Kip1 was increased in diabetic SHR but it was not modified by antihypertensive treatment. Strict blood pressure control, in diabetic SHR independently of the class of antihypertensive agent, restores glomerular hypertrophy and renal cellular replication, and prevents the increment in glomerular fibronectin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 79, Issue 22, 26 October 2006, Pages 2135-2143
Journal: Life Sciences - Volume 79, Issue 22, 26 October 2006, Pages 2135-2143
نویسندگان
Roberto Bleuel Amazonas, José B. Lopes de Faria,