کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2558004 1125744 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence for the presence of noradrenergic neurons and their inhibitory action on luteinizing hormone-releasing hormone release in cultured fetal rat hypothalamic cells
ترجمه فارسی عنوان
مدارک و شواهد برای حضور نورون نورآدرنرژیک و عمل بازدارنده آنها در لوتئینیزه کننده ترشح هورمون آزاد کننده هورمون در سلول های هیپوتالاموس جنین موش کشت شده
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

The control of LHRH release by catecholamine systems during fetal life (embryonic stages) was studied using hypothalamic neurons in primary cell cultures and an attempt was made to characterize the receptor type involved. Phenylephrine and clonidine, respectively α1 an α2 adrenoreceptor agonists, both inhibited LHRH release. These agonist inhibitory induced-effects were antagonized by the respective α1 and α2 adrenoreceptor antagonists (prazosin and rauwolscine). Both prazosin and rauwolscine applied alone induced a marked increase in LHRH release. Similarly, inhibition of catecholamine synthesis obtained by α-methyl-para-tyrosine (α-MT) led to a significant increase in LHRH release. The stimulatory effects induced by α1 and α2 adrenoreceptor antagonists or by α-MT on LHRH release suggest the presence of noradrenergic and/or adrenergic cells in fetal hypothalamic cultures. Therefore, catecholamine contents were measured in fetal hypothalamic cells in culture. Measurable amounts of norepinephrine and dopamine were found in cells, although epinephrine was undetectable. These results show: 1 - noradrenergic cells are present in primary culture of fetal hypothalamic cells. 2 - This intrinsic hypothalamic noradrenergic system exerts an inhibitory control on LHRH release at an early stage of development through α1 and α2 adrenoreceptors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 52, Issue 25, 1993, Pages 2017-2025