کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2560637 1126463 2019 11 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Inhibition of enkephalin degradation in the guinea pig ileum
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Inhibition of enkephalin degradation in the guinea pig ileum
چکیده انگلیسی
Guinea pig ileum tissue preparations contain enzymes which degrade both leucine and methionine enkephalin by cleavage of the N-terminal tyrosine residue. Similar enkephalin degrading activity is also found in the fluid bath surrounding ileum tissue preparations and appears to arise from serum and broken cell enzymes. Chelating agents such as 1,10-phenanthroline and 8-OH quinoline are effective inhibitors of enkephalin destruction by these enzymes but in the concentrations necessary to inhibit all enzyme activity, they disturb the contractility of the ileum during in vitro bioassays. The presence of enkephalin degrading enzymes and the lack of appropriate peptidase inhibitors may hinder the determination and quantification of enkephalin release in this tissue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 23, Issue 20, 13 November 1978, Pages 2019-2029
نویسندگان
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