کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2577527 1561467 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Profile of bioactive compounds of Capparis spinosa var. aegyptiaca growing in Egypt
ترجمه فارسی عنوان
مشخصات ترکیبات زیستی Capparis spinosa var. aegyptiaca در حال رشد در مصر
کلمات کلیدی
Capparis spinosa؛ LC-HRESI-MS-MS؛ فلاونوئیدها؛ ایزوتوسیانات؛ سمیت سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
چکیده انگلیسی

The present study was designed to investigate polyphenolic and sulphur contents of the aerial parts of Capparis spinosa var. aegyptia (Lam.) Boiss., Capparaceae, wildly growing in Egypt. The chemical compositions of the water distilled essential oil were investigated by GC/MS analysis where the major constituent of the oil was methyl isothiocyanate (24.66%). Hydroethanolic extract was evaluated by LC-HRESI-MS–MS in both positive and negative modes. Forty-two compounds were identified including quercetin, kaempferol and isorhamnetin derivatives in addition to myricetin, eriodictyol, cirsimaritin and gallocatechin derivatives. Quercetin tetrahexoside dirhamnoside as well as kaempferol dihexoside dirhamnoside have not been identified before in genus Capparis. Phenolic acids, such as quinic acid, p-coumaroyl quinic acid and chlorogenic acid were also identified. Evaluation of cytotoxic activity of hydroethanolic extract against three human cancer cell lines (MCF-7; breast adenocarcinoma cells, Hep-G2; hepatocellular carcinoma cells and HCT-116; colon carcinoma) using 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay showed significant effect with IC50 values 24.5, 24.4 and 11 μg/ml, compared to Doxorubicin as a standard cytotoxic drug. C. spinosa revealed itself as a promising candidate for nutraceutical researches.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revista Brasileira de Farmacognosia - Volume 26, Issue 4, July–August 2016, Pages 514–520
نویسندگان
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