کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2579883 1561585 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
C5 induces different cell death pathways in promastigotes of Leishmania amazonensis
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
C5 induces different cell death pathways in promastigotes of Leishmania amazonensis
چکیده انگلیسی


• C5 induces mitochondrial depolarization in Leishmania amazonensis.
• C5 induces oxidative damage in L. amazonensis.
• C5 induces different cell death pathways in L. amazonensis.

Leishmaniasis is a neglected infection that is caused by Leishmania protozoa, affecting millions of people worldwide, mainly in tropical and subtropical regions. This disease has different clinical forms: cutaneous, mucocutaneous, and visceral. The drugs that are currently available for the treatment of this infection have limitations, such as high toxicity, long-term treatment, and leads to drug-resistant strains. Numerous studies, in various experimental models, have sought to develop more effective and less toxic chemotherapeutic agents against leishmaniasis. In the present study, we evaluated the mechanism of cell death that is induced by n-benzyl 1-(4-methoxy)phenyl-9H-β-carboline-3-carboxamide (C5) against Leishmania amazonensis. C5 increased reactive oxygen species production, depolarization of the mitochondrial membrane, DNA fragmentation, decrease of cell volume, lipoperoxidation, the accumulation of lipid bodies, and acidic vesicular organelles (AVOs) and caused the intense formation of autophagic compartments in L. amazonensis promastigotes. The results indicate that C5 causes L. amazonensis death through different pathways.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 256, 25 August 2016, Pages 16–24
نویسندگان
, , , , , , , ,