کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2582867 | 1561703 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Waterborne psychoactive drugs impair the initial development of Zebrafish
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
The contamination of rivers and other natural water bodies, including underground waters, is a current reality. Human occupation and some economic activities generate a wide range of contaminated effluents that reach these water resources, including psychotropic drug residues. Here we show that fluoxetine, diazepam and risperidone affected the initial development of zebrafish. All drugs increased mortality rate and heart frequency and decreased larvae length. In addition, risperidone and fluoxetine decreased egg hatching. The overall results points to a strong potential of these drugs to cause a negative impact on zebrafish initial development and, since the larvae viability was reduced, promote adverse effects at the population level. We hypothesized that eggs and larvae absorbed the drugs that exert its effects in the central nervous system. These effects on early development may have significant environmental implications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 41, January 2016, Pages 89-94
Journal: Environmental Toxicology and Pharmacology - Volume 41, January 2016, Pages 89-94
نویسندگان
Fabiana Kalichak, Renan Idalencio, João Gabriel S. Rosa, Thiago A. de Oliveira, Gessi Koakoski, Darlan Gusso, Murilo S. de Abreu, Ana Cristina V. Giacomini, HeloÃsa H.A. Barcellos, Michele Fagundes, Angelo L. Piato, Leonardo J.G. Barcellos,