Effect of enrofloxacin and chlorpyrifos on the levels of vitamins A and E in Wistar rats

• Enrofloxacin (ENR) and chlorpyrifos (CPF) reduce the content of vitamins A and E in the liver.
• CPF significantly decreased vitamins A and E level in the initial period of the experiment.
• Co-exposure to ENR and CPF resulted in less pronounced changes compared to CPF administration only.
• The vitamin levels did not reach the control values until the completion of the study.

This study investigates the effects of enrofloxacin and chlorpyrifos, and their combination on vitamin A and E concentrations in the liver of rats. Results of this study indicated a reduction in the contents of vitamins A and E in the liver, which persisted for the entire period of the experiment. Vitamins A and E concentrations were slightly decreased (2–7%) in enrofloxacin-treated rats. In the group of rats intoxicated with chlorpyrifos, a significant decrease in the level of vitamin A was observed up to the 24th hour, and for vitamin E up to the 3rd day from the discontinuation of intoxication with the compounds under study. In the enrofloxacin-chlorpyrifos co-exposure group reduced vitamins A and E level was also noted. The greatest fall in vitamin A level was observed after 3 h, while the contents of vitamin E decreased progressively up to the 3rd day. Changes in this group were less pronounced in comparison to the animals intoxicated with chlorpyrifos only.