Evaluation of ameliorative potential of selenium on carbendazim induced oxidative stress in male goats

• Carbendazim exposure leads to enhanced lipid peroxidation.
• The blood GSH levels and total antioxidant activity followed declining trend.
• Significant incline in the activity of SOD, CAT, GPx, GR, GST and G6PD was recorded.
• Carbendazim produced marked alterations in antioxidant status in bucks.
• Selenium supplementation provided some amelioration as evidenced by lesser extent of alterations in antioxidant enzymes.

In the present investigation, ameliorative effect of selenium on carbendazim induced oral sub chronic toxicity in bucks was assessed by studying various indices of antioxidant defense system. Bucks were randomly divided into four groups of four animals each. Group I served as control, Group II was orally drenched carbendazim at the dose rate of 50 mg/kg body weight for 90 consecutive days. Group III was orally administered selenium in the form of sodium selenite at the dose rate of 0.05 mg/kg body weight for 90 consecutive days. Group IV was orally administered carbendazim along with selenium at the same dosages as Group II and III. Prolonged administration of carbendazim produced oxidative stress in goat bucks as evidenced by increase in lipid peroxidation and decline in total antioxidant capacity. The increase in the activity of antioxidant enzymes was not sufficient to prevent pesticide induced oxidative stress. Selenium supplementation provides some amelioration against this effect. Further study is needed to prove ameliorative potential of this antioxidant against carbendazim induced toxicity in goat bucks.