کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2690028 1143246 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Leptin and insulin response to long-term total parenteral nutrition depends on body fat mass
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
Leptin and insulin response to long-term total parenteral nutrition depends on body fat mass
چکیده انگلیسی

SummaryBackground & aimsCirculating leptin and insulin concentrations are physiologically representing energy homeostasis. However, the artificial situation of long-term total parenteral nutrition (TPN) and its effects on serum leptin and insulin is not fully understood.MethodsWe studied 42 gastroenterological patients who received TPN for 19±11 days. Serum leptin and insulin levels as well as body composition assessed by bioelectrical impedance analysis were evaluated on days 0, 7 and 14. Insulin sensitivity was estimated by calculating the QUICKI.ResultsBefore the start of TPN, leptin correlated positively with female gender (P<0.03P<0.03), BMI (P<0.02P<0.02), fat mass (P<0.02P<0.02), insulin levels (P<0.001P<0.001) and QUICKI (P<0.001P<0.001). Within the first week of TPN, an increase of leptin levels was found only in patients with a body fat mass of >30% (P<0.02P<0.02). As these were predominantly women, their leptin levels increased likewise (P<0.003P<0.003). In regression analysis, fat mass (P<0.001P<0.001), female gender (P<0.04P<0.04), insulin levels (P<0.03P<0.03), and i.v. glucose supply rates (P<0.05P<0.05) were independently associated to leptin levels.ConclusionsTPN—especially glucose—induces a neurohumoral response as shown here for leptin and insulin that is mainly depending on the fat mass. Better understanding of this regulatory mechanism during artificial nutrition could offer a new approach to improve its therapeutic effects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Nutrition - Volume 25, Issue 5, October 2006, Pages 773–779
نویسندگان
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