کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2700583 1565133 2016 4 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Successful cataract surgery in a patient with refractory Wegener’s granulomatosis effectively treated with rituximab: A case report
ترجمه فارسی عنوان
عمل جراحی آب مروارید موفق در یک بیمار مبتلا به گرانولوماتوز وگنر نسوز با درمان موثر ریتوکسیماب: گزارش یک مورد
کلمات کلیدی
آنتی بادی های ضد CD20؛ آب مروارید؛ یووئیت؛ ریتوکسیماب؛ وگنر؛ گرانولوماتوز
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی چشم پزشکی
چکیده انگلیسی

Wegener’s granulomatosis is a granulomatous disorder associated with systemic necrotizing vasculitis. Eye involvement occurs in approximately 50% of Wegener’s granulomatosis patients and is an important cause of morbidity. Conventional treatment-related morbidity and failure have led to studies of alternative treatment modalities. In this case of a 35-year-old man with severe Wegener’s granulomatosis, conventional therapy failed to induce remission. Despite the standard immunosuppressive therapy, progression of the disease was observed, mainly with ocular manifestations and renal impairment. Rituximab was given intravenously and led to remission of both systemic and ocular manifestations of the disease. After 1 year of disease quiescence, he was admitted one week after his third regularly-scheduled rituximab treatment and was started on intravenous methylprednisolone, 500 mg/day for 3 days, before cataract surgery. Subsequently, the patient underwent phacoemulsification cataract surgery in his left eye. Six months later, in the same manner he underwent uneventful phacoemulsification cataract surgery in the right eye with a favorable outcome in both eyes. Conclusion: In this patient, rituximab was a well-tolerated and effective remission induction agent for severe refractory Wegener’s granulomatosis and led to successful cataract surgery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Saudi Journal of Ophthalmology - Volume 30, Issue 3, July–September 2016, Pages 194–197
نویسندگان
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