کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2702189 1144523 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Older Women Benefit from Thrombolysis as Much as Older Men
ترجمه فارسی عنوان
زنان سالخورده از ترومبولیسم به اندازه مردان مسن تر بهره مند می شوند
کلمات کلیدی
سن؛ alteplase؛ مسن؛ جنسيت؛ ایسکمی؛ سکته مغزی؛ ترومبولیز؛ زنان
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مغز و اعصاب بالینی
چکیده انگلیسی

BackgroundAlthough the incidence of stroke among older people increases, the use of intravenous thrombolysis has initially been restricted in the elderly. However, more people aged more than 80 years, a majority of them women, may benefit from thrombolysis. Therefore characteristics, outcome, and complications in older women (aged more than 80 years) undergoing thrombolysis are studied and compared to older men and to younger women (aged less than 80 years) to detect any gender and age differences.MethodsRetrospective study of stroke patients treated with thrombolysis based on data collected from medical records. Outcome and complications were analyzed in 3 groups in relation to age and gender.ResultsFrom a total of 108 patients treated with thrombolysis, 94 could be included in the study (36 women ≥80 years, 23 men ≥80 years, and 35 women <80 years). Improvement over the first 24 hours and at 3 months, and mortality were comparable between older women and men. Older women had more major strokes, a higher mortality, and 3-month morbidity than younger women. There was no significant difference in intracranial hemorrhage between the groups.ConclusionsWe found no significant difference between older women and men in outcome and mortality after thrombolysis. Older women suffered from more severe strokes, and had a higher mortality and worse outcome than younger women. The frequency of intracranial hemorrhage was comparable. Given the higher percentage of older women suffering from more severe strokes, our results emphasize that thrombolysis should not be withheld exclusively based on age.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Stroke and Cerebrovascular Diseases - Volume 25, Issue 8, August 2016, Pages 1882–1886
نویسندگان
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