کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2732963 1404042 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reducing cardiac after-load by lowering blood viscosity in patients with familial hypercholesterolemia – A pilot study. Possible mechanism for occurrence of anemia in chronic heart failure patients?
ترجمه فارسی عنوان
کاهش قلبی پس از قاعدگی با کاهش ویسکوزیته خون در بیماران مبتلا به هیپرکلسترولمی خانوادگی - یک مطالعه آزمایشی. مکانیزم احتمالی برای بروز کم خونی در بیماران مبتلا به نارسایی مزمن قلب؟
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

Anemia is present in more than 40% of the patients with chronic heart failure (CHF), especially in those with reduced ejection fraction. The etiology is not yet understood. Hematocrit is a major determinant of whole blood viscosity, which is an important factor of the total peripheral resistance for the heart. Therefore, lowering blood viscosity may reduce after-load for the failing heart. Patients with homozygous familial hypercholesterolemia (HFH) are characterized by markedly elevated low-density lipoprotein (LDL) cholesterol levels and premature ischemic heart disease. Selective LDL-cholesterol apheresis in HFH patients to remove LDL from the circulation is the recommended treatment of this condition and has been shown to reduce whole blood viscosity. The level of B-type Natriuretic Peptide (BNP) is a parameter of filling conditions in the heart and is predominantly induced by cardiac after-load. BNP was measured in 4 consecutive HFH patients before and after treatment with selective LDL-apheresis. We observed that 20% reduction of blood viscosity by LDL-apheresis in these patients resulted in 40% lower levels of BNP. In chronic heart failure patients, anemia might be a compensatory mechanism of the organism in order to reduce after-load for the failing heart by lowering blood viscosity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cor et Vasa - Volume 58, Issue 4, August 2016, Pages e374–e378
نویسندگان
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