کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2771271 1151728 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Macrophage activation syndrome: A severe and frequent manifestation of acute pancreatitis in 362 childhood-onset compared to 1830 adult-onset systemic lupus erythematosus patients
ترجمه فارسی عنوان
سندرم فعال سازی ماکروفاژ: بروز شدید و مکرر پانکراتیت حاد در 362 مورد شروع شده در دوران کودکی در مقایسه با 1830 بیمار مبتلا به اریتماتوی لوپوس سیستمیک شروع شده در دروه بزرگسالی
کلمات کلیدی
پانکراتیت؛ سندرم فعال سازی ماکروفاژ؛ اریتماتوی لوپوس سيستميک کودکي؛ کورتیکواستروئید؛ سرکوب کننده سیستم ایمنی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
چکیده انگلیسی

ObjectiveWe previously reported a case series of acute pancreatitis (AP) and macrophage activation syndrome (MAS) in childhood (cSLE) patients; however, there are no data regarding the comparison of AP and MAS in large populations of cSLE and adult SLE (aSLE).MethodsA study included 362 cSLE and 1830 aSLE patients. MAS was diagnosed according to preliminary diagnostic guidelines and AP according to the presence of abdominal pain or vomiting associated to an increase of pancreatic enzymes and/or pancreatic radiological abnormalities. Demographic data, clinical features, SLEDAI-2K, SLICC/ACR-DI, and treatment were assessed.ResultsAge in MAS patients was significantly lower compared with those without this complication [15 (8.8–55) vs. 33.5 (10.2–45.7) years, p = 0.007]. The frequencies of fever (94% vs. 37%, p = 0.001), leucopenia (82% vs. 19%, p = 0.0001), thrombocytopenia (65% vs. 19%, p = 0.013), hypertriglyceridemia (87% vs. 42%, p = 0.037), and hyperferritinemia (93% vs. 37%, p = 0.011) were also more frequently observed in AP patients with MAS compared in AP patients without MAS. Fever and hyperferritinemia concomitantly were more frequent in the former group (86% vs. 12%, p = 0.0015). Higher and significant frequency of AP in cSLE compared to aSLE patients [12/362 (3.3%) vs. 20/1830 (1.1%), p = 0.003], with similar AP duration [22 (6–60) vs. 15 (4–90) days, p = 0.534]. MAS (85% vs. 30%, p = 0.003) and death by MAS complication (31% vs. 0%, p = 0.017) were significantly higher in children compared with aSLE.ConclusionsThis study provides novel data demonstrating that MAS occur in the majority of cSLE with AP with a higher mortality compared to aSLE. In addition, we identified in AP patients, a cluster of MAS clinical and laboratorial parameters more associated with this complication.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Arthritis and Rheumatism - Volume 45, Issue 6, June 2016, Pages 706–710
نویسندگان
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