کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2778470 | 1152832 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Arachidonic acid induces augmented vasoconstriction via cyclooxygenase 1 in the aorta from rats fed a high-fat diet
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
As childhood obesity is increasing, its affects on the cardiovascular system remain unclear. Cyclooxygenase (COX) enzymes metabolize arachidonic acid (AA) into vasoactive prostanoids and their expression is altered in hypertensive animal models. We hypothesized that there would be augmented vasoconstriction to AA, mediated via COX 1 in rats fed a high-fat (HF)-diet for 10 weeks (from 3 to 13 weeks old) compared to those fed regular rat chow. AA induced vasoconstriction was augmented in the aorta from rats fed a HF-diet compared to control. Inhibitors to AA metabolism suggest that COX 1 activity predominates in rats fed a HF-diet. Western blot analysis showed that COX 1 but not COX 2 protein expression was increased in aortic rings stimulated with AA from the rats fed the HF-diet. These results suggest that vasoconstriction induced by AA is augmented in rats fed the HF-diet due to increased COX 1 expression and activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids - Volume 75, Issue 1, July 2006, Pages 43-49
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids - Volume 75, Issue 1, July 2006, Pages 43-49
نویسندگان
Anita D. Smith, Anne M. Dorrance,